Speaker Biography

BRAHMI Mostapha

Dr Moulay-Tahar University, Algeria

Title: ANTIDEPRESSANT AND ANXIOLYTIC EFFECTS OF Mentha Spicata ESSENTIAL OIL AGAINST CHRONIC Co-EXPOSURE TO LEAD AND MANGANESE DURING DEVELOPMENT IN WISTAR RATS

BRAHMI Mostapha
Biography:

Brahmi Mustapha Ph.D. in biochemistry and experimental toxicology and member in the laboratory of biotoxicology, pharmacognosy and valorization of plants at the university of saida algerie

Abstract:

 The objective of this study is to evaluate the changes induced by lead and manganese by using the neurobehavioral and biochemical approach in young rats during the gestation and lactation period. As well as the effectiveness of the essential oil of mint, to restore or not these effects by treating the previously intoxicated rats by a daily dose of intraperitoneal injection of 0.1 ml HE / kg during a period of 21 days . However, the extraction by hydro-distillation, made it possible to obtain an HE with a yield of 1.38%. Chronic exposure to lead at a concentration of 2.84 mg / ml and manganese at a concentration of 4.79 mg / ml during the developmental period resulted in a decrease in body weight of young rats (J21) and reduced brain weight compared to controls. However, the use of different techniques relating to behavior tests: the raised cross labyrinth test (EPM) and the open field clearly reveal that MnCl2 Pb intoxication causes a major depressive state and a locomotor hypoactivity with exploratory disability in young rats from intoxicated females during the developmental period compared to controls. This is explained by the deleterious effects of Pb and Mn on dopaminergic and serotoninergic transmission. In contrast, results from biochemical assays showed that lead and Mn induced hypocalcemia, hypomagnesemia, hypo albuminemia, hypercholesterolemia, decreased total iron, and increased ALP activity. Moreover, the administration of the essential oil of Mentha spicata allowed to observe a regain of body weight, a regulation of neurobehavioral disturbances and different biochemical parameters which justify the great importance of the mint in the traditional medicine and these therapeutic virtues.