Mohamed Eddouks
Moulay Ismail University, Morocco
Title: Effect of aqueous Corrigiola telephiifolia extract on glucose metabolism in normal and diabetic rats
Biography:
Abstract:
Introduction: Corrigiola telephiifolia Pourr, is a perennial species, woody distributed throughout the north of Africa. This plant is used in traditional Mediterranean preparations and has many traditional uses especially treatment of diabetes.
Aim of the study: the current research was carried out to evaluate the antidiabetic effect of aerial parts aqueous extract (APAE) of Corrigiola telephiifolia (C. telephiifolia) on both normal and streptozotocin(STZ)-induced diabetic rats treated at a dose of 5 mg/kg body weight for fifteen days. In addition, a preliminary pytochemical screening for various components was realized.
Results: Single oral administration of the APAE of C. telephiifolia (5mg/kg) showed no significant change in glycaemia of normal and STZ-induced diabetic rats. In contrast repeated oral administration of C. telephiifolia reduced blood glucose levels from 4.11±0.10mmol/L to 3.16±0.16 mmol/L (p<0.01) 15 days after administration in normal rats. Furthermore, blood glucose levels were decreased from 17.84±1.75mmol/L to 1.93±0.33 mmol/L (p<0.0001) in STZ diabetic rats after fifteen days of treatment. According to the oral glucose tolerance test, C. telephiifolia (5 mg/kg) was shown to prevent significantly the increase on blood glucose levels in normal treated rats 30 min after glucose administration when compared to the control group. Concerning the preliminary phytochemical screening of C. telephiifolia, several compunds have been found such as polyphenols, flavonoids, saponins, mucilage and terpenoids.
Conclusion: The results show that aqueous extract of C. telephiifolia possesses significant antihyperglycemic activity.