Name: Natural Compounds 2018
Start: 2018-06-18
End: 2018-06-20
Location: France

Renowned Speakers

We’ve invited the top most influential speakers from around the world to give inspirational talks and lead practical workshops.

Dr. Christina Marrongelli

Adjunct Professor, The Medical University of South Carolina USA

Biography

Nial DeMena

CEO, Manna Molecular Science USA

Elvira Gaspar

Assistant Professor, New University of Lisbon Portugal

Biography

Manal Mortady Hamed

Professor, Theodor Bilharz Research Institute Egypt

Biography

Diana Marie Dummer

Independent Consultant at Natural Products Industry USA

Gaurav Rajauria

Natural Product Chemist at University College Dublin (UCD) Ireland

Ping Chin Lee

Associate Professor, Universiti Malaysia Sabah Malaysia

Anil Kumar Saksena

KING GEORGES MEDICAL UNIVERSITY India

Conference Information

About Conference

Natural Compounds 2018 Countdown

On behalf of PULSUS Conferences, we announce “World Congress on Pharmacology and Chemistry of Natural Compounds” which will be held from June 18-19, 2018 at Paris, France. The conference will be organized around the theme “Exploring new trends & Innovations in Pharmacology and Natural Compounds’’. Natural compounds 2018 is mainly focuses on Uses, Side effects, Mechanism of action of drugs and scientific study of the structure of Natural compounds.

The Conference provides the research work of pharmacology and chemistry of natural compounds expertise from various scientific backgrounds and the same can be perceived by pharmacologists, scientists and students. Natural compounds 2018 brings unique platform for scientists, researchers, academicians, professors and students to share their knowledge and views also presenting research about latest pharmacological activities of drugs and chemical properties, reactions of Natural compounds. PULSUS provides an opportunistic environment and vibrant podium through these auspicious events to amplify these steps and meet the highest demand ever, by reflexive and cerebrative connections.

Pharmacology is the study of drugs, how they interact with other molecules in the body. This field is divided in to two parts: Pharmacodynamics and Pharmacokinetics, which means Pharmacokinetics is concerned with what your body does with a drug and pharmacodynamics is concerned with what drug does to your body. Natural Compounds play crucial role in modern drug development. Chemistry and pharmacology of Natural Compounds presents cutting-edge research in the chemistry of bioactive Natural Compounds and determines how natural product research continues to make significant contributions in the new drug discovery and development.

Scientific Session

Session 01: Chemistry of Natural Compounds

Natural Compounds are synthesized in living organisms by a sequence of reactions usually catalysed by enzymes. Natural product is a chemical substance produced by living organism; a term used commonly in reference to chemical substances found in nature that have distinctive pharmacological effects. There are many examples of important natural compounds as drugs. Coumarins are the largest group of 1-benzopyran derivatives found in plants and it can be prepared with the Perkin reaction between salicylaldehyde and acetic anhydride. Within the field of organic chemistry, Natural Compounds are prepared by separating them from biological sources that are produced by the Metabolic pathways.

Related Conferences

International Conference and Exhibition on Natural Products, Medicinal Plants & Marine Drugs, June 11-12, 2018, Rome, Italy, World Congress on Pharmacology and Toxicology May 24-25, 2018, Osaka, Japan, World Congress of Basic and Clinical Pharmacology, July 1-6, 2018, Kyoto, Japan, International Conference on Pharmacognosy and Medicinal Plants, April 16-17, 2018, Amsterdam, Netherlands, International Conference on Organic Chemistry, June 11 - 12, 2018, Copenhagen, Denmark, Marine Natural Products Conference, March 4-9, 2018, Ventura, USA, International Conference on Medicinal Plants and Natural Products, June 6-7, 2018, San Francisco, USA.

Related Associations

American Herbal Products Association (AHPA), Society for Medicinal Plant and Natural Product Research, Society for Ethnopharmacology, British Herbal Medicine Association (BHMA), American Herbal Product Association (AHPA), American Association of Naturopathic Physicians (AANP), Hungarian Society of Natural Products

Session 02: New Technology in Natural Compounds

Natural Compounds have been a rich source of lead molecules in drug discovery. NMR spectroscopy approaches to mixture analysis that demonstrates the commonalities between traditional natural products chemistry and metabolomics. Isolating bioactive compounds from mixtures can be done in two different ways. The mixture can either be separated on the source of its behaviour in a biological assay, or by separating molecules from the mixture that have interesting chemical structures. Now a day’s spectroscopic techniques are used directly to screen natural product. Mass Spectrometry in the form of methods such as ESI-ICFTMS and FACS-MS. As well as NMR methods such as SAR by NMR and STD-NMR have been utilized to effectively screen molecular libraries. In general promising advances in mass spectrometry, NMR and other technologies are making it possible to overcome the challenges encountered in screening natural products in today’s drug discovery environment.

Related Conferences

European Organic Chemistry Congress, March 01-03, 2018 London, UK, International Conference and Exhibition on Natural Products, Medicinal Plants & Marine Drugs, June 11-12, 2018, Rome, Italy, International Conference on Organic Chemistry, June 11-12, 2018, Copenhagen, Denmark, Marine Natural Products Conference, March 4-9, 2018, Ventura, USA, International Conference on Medicinal Plants and Natural Products, June 6-7, 2018, San Francisco, USA, World Congress of Basic and Clinical Pharmacology, July 1-6, 2018, Kyoto, Japan, Edition of International Conference on Pharmacognosy and Medicinal Plants, April 16-17, 2018, Amsterdam, Netherlands.

Related Associations

European Herbal & Traditional Medicine Practitioners Association, Natural Products Association, Australian Natural Therapists Association (ANTA), Naturopaths & Herbalists Association of Australia, Canadian Natural Products Association (CNPA), Indian Pharmacological Society, European Plant Science Organization (EPSO)

Session 03: Importance of Natural Compounds in Medicine

Natural products and their derivatives have been used as a source of therapeutic agents. Natural products used for medicinal purpose- the compounds derived from the plants, animals and marine organisms. Now days the natural products are used for many diseases for better prevention as well as therapeutic options. The research on natural products explores a variety of major structures used for the development of new drugs by the pharmaceutical industry. Charaka Samhita is the first dissertation keen to the perceptions and practice of Indian Ayurveda which contains 341 plants derived medicines whereas Sushruta Samhita was keen to surgical practices.

Related Conferences

World Congress on Pharmacology and Toxicology May 24-25, 2018, Osaka, Japan, International Conference and Exhibition on Natural Products, Medicinal Plants & Marine Drugs, June 11-12, 2018, Rome, Italy, World Congress of Basic and Clinical Pharmacology, July 1-6, 2018, Kyoto, Japan, International Conference on Organic Chemistry, June 11-12, 2018, Copenhagen, Denmark, International Conference on Medicinal Plants and Natural Products, June 6-7, 2018, San Francisco, USA, Edition of International Conference on Pharmacognosy and Medicinal Plants, April 16-17, 2018, Amsterdam, Netherlands, Marine Natural Products Conference, March 4-9, 2018, Ventura, USA.

Related Associations

French Society of Ethnopharmacology, American Society for Clinical Pharmacology and Therapeutics (ASCPT), American Society for Pharmacology and Experimental Therapeutics (ASPET), European Society of Ethnopharmacology, French Society of Pharmacology, The American Society of Pharmacognosy, International Society for the Development of Natural Products (ISDNP)

Session 04: Natural compounds for Various Diseases

A huge number of populations were affected by chronic diseases such as neurodegenerative disease, cardiovascular diseases, obesity and cancer. Current studies show that natural compounds derived small molecules may have potential in reducing risk of chronic diseases. Amongst the natural resources for new bioactive chemicals, terrestrial plants, bacteria and fungi have usually played a key role whereas many interesting new active molecules are found in marine life forms. Such molecules of natural origin that show a hopeful potential to act against the pathogens responsible for neglected tropical diseases.

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Session 05: Separation and purification of natural compounds

Despite of substantial developments of extraction and separation techniques, isolation of natural products is still a challenging task. In this following session, major tools which are used in plant authentication will be discussed. Wide ranges of methods are available for identification of biological materials (plants, marine organisms, microorganisms) which are applicable to different degrees for confirmation of unknown material. A combination of several methods might be necessary for clear validation. The various processes used for extraction are: Maceration, Infusion, Digestion, Decoction and Percolation.

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Session 06: Standardization of Herbal Medicines

Herbal formulations are gradually required out as medicinal products, nutritional supplements and cosmetic in recent years. Herbal medicines originated firstly in the Asian countries and today they are being seen as therapeutic agents for several chronic diseases. Standardization of herbal medicines is the process of prescribing a set of standards or inherent characteristics, constant parameters, definitive qualitative and quantitative values that carry an assurance of quality, efficacy, safety and reproducibility. Herbal drugs are a finished product which is categorised depending upon the ingredients contained in them. Several quality standards as laid down in formularies, pharmacopoeias or manufacturing operation are followed through legal obligatory good manufacturing practices by regulatory authorities.

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Session 07: Classification of Natural Products

Most of the natural sources of drugs are obtained from minerals that are both organic and inorganic in nature. Therapeutics has promoted from numerous drug classes derived from natural plant sources. The compounds are classified into four different groups according to their biosynthetic origin such as alkaloids, phenylpropanoids, polyketides and terpenoids whereas 200,000 structures of natural products from plants are known, only selected groups and compounds are present.

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Session 08: Drug innovation and Organic screening of Natural Products

Organic Synthesis is a compound creating activity repeatedly focused on biologically active small molecules. Over a century chemists and biologists have been exploring the functions of small molecules in living systems. Methods require the genetic engineering of model systems whereas modern organic synthesis is playing progressively prominent role. Modern classifications include, but are not limited to, screening in cell lines utilizing very modern techniques (a high content screen) that are designed to show interactions within cells when treated with an "agent". In 1990s, the pharmaceutical industries used the high-throughput screening of chemicals against potential targets was highlight though in parallel, screening of natural product diminished.

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Session 09: Pharmacology of Natural Compounds

Herbs were once the essential of medication and pharmacology, and around a section of drugs are derived from chemical individuals in medicinal plants. Herbs, vitamins, minerals, and other dietary supplements are very popular, pharmacologically active products.

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Session 10: Role of Natural Compounds in Drug discovery

The natural products obtained from mainly plants, animals, marine sources, microbial world, venoms and other toxins. Natural compounds are the richest source of biologically active compounds whereas today’s medicine obtained directly from natural source or developed from a chief compound initially obtained from a natural source. Moreover natural products and their derivatives have been recognized for many years as a source of therapeutic agents and structural diversity. Natural products are with an excellent chemical diversity and long term of usage with wide acceptance.

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Session 11: Natural compounds for Cancer Treatment and Prevention

Cancer is the second leading cause of death in the United States. Despite the estimated 565,650 deaths in 2008 of Americans as a result of cancer, it is mostly a preventable disease. Chemoprevention is a means of cancer control by which the manifestation of the disease can be entirely prevented, slowed down, or reversed by the administration of one or more naturally occurring and/or synthetic agents. Tea is one of the most broadly consumed beverages and is rich in substances with antioxidant properties. The main natural cancer therapeutics is Tubulin binding agents (Vinca alkaloids, Taxanes) and Topoisomerase inhibitor (Camptothecins, Epipodophyllotoxins, Anthracyclines). Arsenic is a common, naturally occurring substance used in TCM practices for more than 2000 years. Apart from combating malaria and plague, this ancient remedy, containing 95% arsenic trioxide (As2O3), was once applied to cancer therapy. Some of the natural compounds that are useful in the treatment of cancer are Curcumin, Resveratrol, Lycopene, Luteolin, Genistein, and Artemisinin.

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Session 12: Herbal Medicine Side effects and Interactions

Any conventional medicine can have side effects and the side effects are labelled and reported after Clinical trials and research studies have been conducted. Unconventional treatments such as herbs have little or no actual scientific basis. Side effects of herbal medicine depend upon the herbal remedy of dosage and any pharmaceutical medication taken by the patient. The interactions occur of taking herbal medicines with pharmaceutical medications. The common side effects of interaction occur of taking herbal and pharmaceutical medications are: photosensitivity, skin irritation, sleepiness.

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Session 13: Clinical Pharmacology

Pharmacology is a branch of science that deals with the mode of action of drug. Clinical pharmacology is basic science of pharmacology on the use pharmacological principles in medical clinic and towards patient care. Clinical pharmacology repeatedly uses the methods that have been developed by other disciplines such as biology, physiology, analytical chemistry. The consequence of a new compound has to be identified by Invitro and Invivo procedures of pharmacology. Pharmacology and toxicology are interconnected disciplines in the field of biomedical science. There are numerous types of drugs to treat diseases. Some of the drugs act in the Central Nervous System is Sedative-Hypnotic drugs, Anti-seizure drugs, General Anaesthetics, Antipsychotic agents, Antidepressants, Opioid analgesics & antagonists.

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Session 14: Herbal Pharmacology

Herbal pharmacology deals with the chemical constituents, mechanism of action, routes of absorption, metabolism and excretion of particular plant. Herbal pharmacology uses organic herbs and plants to stimulate physical, demonstrative, and spiritual health. Identifying the pharmaceutical mechanisms of herbal drugs poses frequent challenges not generally faced by conventional drugs .Compared to the mechanism of action of herbal drugs; conventional drug pharmacology is relatively straightforward.

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Session 15: Pharmacognosy and Phytochemistry

Pharmacognosy is the study of the physical, chemical and biological properties of drug or drug substances of natural origin also the search for new drugs from natural sources. Plant preparations are said to be medicinal or herbal when they are used to promote health beyond basic nutrition. Crude drugs is known to the natural product that has not been in advanced in condition by any process or treatment beyond that which is essential for its proper packaging and prevention from deterioration. Phytochemistry is the study of phytochemicals or branch of chemistry that deals with biochemical processes related with plant life and the chemical complexes produced by plants. Medicinal plants are a rich source of bioactive phytochemicals. It is well known that plants produce chemicals to protect themselves, but recent researches demonstrate that many phytochemicals can also protect human against diseases.

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Session 16: Scope of Pharmacology

Pharmacology is the study of substances that interact with living organisms through chemical processes, by binding to regulatory molecules and stimulating normal body processes. Scope is an area in which something Acts or Operates or Controls with the subject. There are three phases in drug development; drug discovery phase, preclinical phase, clinical trial phase. The scope of pharmacology is rapidly expanding and provides the rational basis for the therapeutic use of the drug. Usually some sort of biological screen is used to select among organic compounds for optimum pharmacological activity.

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Session 17: Bioprospecting of Medicinal Plants

Bioprospecting is the method of discovery and commercialization of new products based on natural resources. Plants, fungi, animals, bacteria and plenty of other organisms may contain natural compounds that could be of benefit for us. More recently, bioprospecting has also included research conducted into indigenous knowledge about the use of biological resources. Finally, bioprospecting must be taken into account the rights of original communities, their knowledge and traditions in terms of the Research and Commercialization of their heritage.

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Session 18: Branches of Pharmacology

The study of drugs, including their origin, nature, chemistry, uses and adverse effects and also includes the study of substances that bind to regulatory molecules and activate/inhibit normal body processes is known as pharmacology. Major divisions of pharmacology are pharmacokinetics (what body does to the drug) and pharmacodynamics (what drug does to the body). Pharmacokinetics deals with drug dose, routes of administration and absorption, distribution, metabolism and excretion whereas pharmacodynamics deals with the mechanism of action, pharmacological effects, indication and contraindication of use and adverse effects of drugs.

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Session 19: Synthesis of Bioactive Compounds

Natural product synthesis aims to prepare a complex target molecule such that the product is analytically identical to the naturally occurring compound, termed a natural product. It is used for structure confirmation, but also as a test for new synthetic methodology and sometimes to assist in identifying how the compound is made naturally.

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Session 20: Pharmacology and Therapeutics

Therapeutics is a branch of medicine dealing with an application of therapies to diseases. A drug can be defined like any compound introduced into a living organism, in order to prevent or to cure a disease. Therapeutic is the part of the medicine which studies and applies the means suitable to therapy and to relieve the patients. The mode of action of the majority of drugs is known. The drugs whose mechanism of action is not explained are generally active only at very high doses, which show their weak affinity for a particular type of target and suppose a diffuse activity on several targets. A therapeutic effect is a significance of a treatment of any kind, the results of which are judged to be necessary and beneficial.

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Session 21: Herbal Drug and Pharmacology market

The worldwide herbal drug market is expected to reach nearly $86.74 billion by 2022, increasing at a CAGR of around 6.8% between 2017 and 2022. The industrialists are focussing on enlightening the quality of herbal products. Around 80% of world’s population using traditional medicines as their healthcare purpose. Pharmaceutical sector held the highest compound annual growth rate from 2016 to 2022.

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Market Analysis

Scope and Importance:

Compounds derived from nature have played a major role in drug discovery. Natural products have pharmacological or biological activity that can be of therapeutic value in treating diseases. Natural Compounds have Provides the source for the majority of FDA-approved agents and continue to be one of the major remaining fields for roots of inspiration for the future drug discovery. The Researchers and Industrialists are focussed on new drug development process for known drugs through investigation of leads obtained from the traditional systems of medicine or other sources. The structural diversity of natural products exceeds that readily achievable by biochemical synthesis, and synthetic analogues can be prepared with improved safety and efficacy, natural products are frequently used as starting points for drug discovery.

Natural Compounds includes various plants and herbs, which can cure a number of ailments. Natural Compounds is broadly understood to increase the body’s capability to ward of diseases. Furthermore, the increasing geriatric population is highly susceptible to acquire the chronic diseases result in enhanced demand for highly efficacious pharmacological drugs. In future the high requirement of efficacious drugs can be effectively met at a faster rate, therefore creating a high potential for biosimulation market growth. Increasing demand can be attributed primarily to the significant cost reduction in clinical trials and drug development & drug discovery process.

Research of Pharmacology and Chemistry of Natural Compounds in PARIS:

Paris is the capital city of France, located in the north-central part of the country. Paris is located at the Centre of the Île-de-France province, which is go across by the Seine, Oise, and Marne rivers. Paris city is ringed with great forests of beech and oak, they are called the “LUNGS OF PARIS” for they help to purify the air in the heavily industrialized region. Paris can be seen as the most fascinating city of Europe and perhaps even as one of the most wonderful city’s worldwide. The evening scene, Eiffel tower and the warm atmosphere will make you feel directly at home. A city as Paris is one that everyone should visit and experience. The most popular districts in Paris are St.-Germain-des-Pres, Montmartre, Opera and Beau Bourg, Invalides, Quartier Latin. Education in Paris and the Île-de-France region services approximately 330,000 people, 170,000 of whom are teachers and professors teaching approximately 2.9 million children and students in around 9,000 primary, secondary, and higher education institutes and organizations

Growth Rate of Natural Compounds:

The Worldwide Biological compounds market is poised to grow at a CAGR of around 9.8% over the next decade to reach around $25.7 billion by 2025. The market is beginning to segment into a number of well-defined categories like skin care, hair care, oral care, cosmetics and other Healthcare products depend upon the Product. The World Health Organization (WHO) estimates that the global market is approximately US $83 billion annually. Natural Compounds can serve as a major way of treating certain conditions or diseases more cost effectively, especially if the herb can be grown locally or county-wide.

The presence of the natural products industry is varying as it grows to $141 billion in sales in 2016. Perceiving the thriving demand for natural products and the rapid growth of new start-ups, traditional large-cap consumer goods companies have looked to evolve by building out their own natural divisions or acquiring smaller rivals. In 2011 the growth of natural products in the market is 11.2 percent. Whereas, in 2011 the natural products industry experienced the growth mostly in Pacific region. According to Grand View Research the growth in natural products industry is estimated to be $25.1 million by 2025. Currently, the market growth of natural products is $11,057.1 million.

Clinical Trials Market:

According to a new report by Grand View Research Inc., global Healthcare CRO industry is expected to reach $45.2 billion by 2022. In 2016, the global clinical trials market size was valued $14.2 billion and estimated to be $22 billion by 2021. Clinical trials market based on phases (I, II, III, IV) trial services. In addition, global clinical trials market is estimated to be $65.2 billion by 2025 according to Grand View Research. The global clinical trials market viewed a worthwhile growth in 2016 and is expected to grow at a CAGR of over 5.5% from 2017-2025. Based on indication, the Autoimmune, oncology, diabetes, cardiovascular, pain management, CNS conditions, obesity, others are predicted to witness the fastest growth. Whereas more than $38 billion is currently spent by healthcare industries towards preclinical and clinical development of oncology therapy products. To conduct clinical trials, interventional study design is the most prominent method across the globe. Whereas, 126,000 trails are currently being conducted by this interventional study design.