ERA University, India
Objectives: Osteoarthritis is a progressively debilitating, inflammatory disorder of synovial joints. As knee is the most affected synovial joint, the maximum research has been carried out on osteoarthritis of knee (KOA). Long term therapy with NSAIDs/Steroids is used for the treatment of KOA, but, due to the associated serious side effect of these drugs, the alternative system of therapies are need of hour. Hence, we planned to evaluate the antioxidant and anti-inflammatory effects of Curcuma longa (CL) extract in the patients of KOA.
Results: The study has proved that long term therapy of KOA with CL extract as an adjuvant with diclofenac provides significant (p<0.05) improvement in pain and relief in discomfort as analysed through Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).
There was improvement in the level of anti-inflammatory biomarker IL-10 and MMP-9 as compared to placebo. Further, the level of antioxidant enzymes such as Superoxide dismutase and Catalase also showed improvement in CL extract group as compared to placebo group. Similarly, Uric acid levels also showed significant reduction (p<0.05) in CL extract group as compared to placebo group.
Conclusion: The improvement in WOMAC and VAS may be subjective; however, the levels of biomarkers are certain objective parameters which confirm the status of anti-inflammatory and antioxidant activity of CL extract in KOA patients.