Natural Compounds 2021

Biography:

Mohamed Eddouks is Professor at Moulay Ismail University, Faculty of Sciences and Techniques Errachidia, Morocco. He is a researcher in Physiology and Pharmacology with a Master Degree in Metabolic and Molecular Endocrinology from University of Paris vi, a specialized certificate in Endocrine Pharmacology from University of Paris vii and PhD degrees in Physiology and Pharmacology from University of Liege, Belgium and Sidi Mohammed Ben Abdellah University, Fez, Morocco. After his post-doctoral fellowship at Department of Physiology, Faculty of Medicine of Montreal, Canada, he is working for the last 16 years on medicinal plants. His work on antidiabetic and antihypertensive plants is well recognized globally.His contribution to this field includes four international books and more than 80 peer-reviewed articles and book chapters of international repute. He is Guest Editor of American Journal of Pharmacology and Toxicology, Lead Guest Editor of an annual special issue published by Evidence-Based and Complementary Alternative Medicine, Regional Editor of the Following journals: American Journal of Food Technology, Journal of Applied Sciences, Trends in Applied Sciences Research and Singapore Journal of Scientific research, Member of Editorial Board of several international journals. He has been honored with the first Prize of Scientific Research in 2008 by the Moroccan Association of Research and Development and the first Prize of the Federation of Arab Scientific Councils in 2016. He has been the Dean of Polydisciplinary Faculty of Errachidia from 2008 to 2012.

Abstract:

Background: Pistachia atlantica Desf, (Anacardiaceae) is an important source of essential oil and phenolic compounds justifying the use of its various parts in traditional medicine.

Objective: The present work aimed to evaluate the antidiabetic and the antioxidant activities of the aqueous extract of leaves of Pistachia atlantica.

Methods: The current study evaluated the effect of a single and repeated (15 days of treatment) oral administration of the aqueous extract of leaves of Pistachia atlantica (PALAE) on blood glucose levels in normal and streptozotocin-induced diabetic rats. Furthermore, its effect on glucose tolerance, histopathological examination of pancreas and liver in accordance with the Hematoxylin-Eosin method were carried out. Likewise the antioxidant activity of this extract was evaluated by the method of trapping of free radical 2, 2- diphenyl-1 picrylhydrazyl (DPPH).

Results: Single oral administration of PALAE reduced blood glucose levels in normal (p<0.05), and STZ diabetic rats (p<0.0001), 6 and 4 hours after administration respectively. Furthermore, this extract had an optimal effect (p<0.0001) in both normal and STZ diabetic rats at 15^th and 7^thdays of treatment respectively. It was also shown to prevent significantly the increase on blood glucose levels 120 min after glucose administration, in both normal (p<0.05), and diabetic (p<0.01) treated rats when compared to the control group. In addition, histopathological analysis highlighted the positive effect of Pistachia atlantica on pancreas and liver. Finally, inhibitory concentrations of 50% of free radicals (IC50) of Pistachia atlantica was equal to 4.85 ± 0.54 µg/ml, while the synthetic antioxidant (BHT) showed an IC50 of 22.67 ±2.17 µg /ml.

Conclucion: the study demonstrates the antihyperglycemic effect of the aqueous Pistachia atlantica extract in diabetic rats which should be mediated through the amelioration of the oxidative stress as well as an improvement in pancreas and liver histology.